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2 0 obj However, below a size of approximately 1-2 µm, the saturation solubility is also a function of particle size. 4 0 obj &�b�����U��NJ 82 A study protocol has been developed to provide a harmonized approach when performing 83 solubility studies. 11. Beyond this saturation concentration, a … 2.84 EXPERIMENTAL CONSIDERATIONS 85 Overall, the API sample should be dissolved/suspended in the buffer, then separated by 86 appropriate methods and, in the end, its concentration should be determined in the liquid 87 phase/supernatant. 3 0 obj endobj stream ... solubility and bulk concentration respectively, A is the surface area and h is the diffusion layer thickness. Saturated solubility study The data for the saturated solubility study is provided in Fig. <>>> <>/ExtGState<>/ProcSet[/PDF/Text/ImageB/ImageC/ImageI] >>/Annots[ 9 0 R] /MediaBox[ 0 0 595.32 841.92] /Contents 4 0 R/Group<>/Tabs/S/StructParents 0>> 3.1 Intrinsic rate of dissolution <> The present study is aimed at increasing solubility of drug using solid dispersion technique. ! endobj Solubility. stream The literature values of pKa lit , intrinsic solubility, S 0 lit , and experimental intrinsic solubility, S 0 exp , developed from solubility-pH profile at two temperatures, 298.2 and 310.2 K The saturation solubility was measured in water or in the presence of surfactant at 32 °C with a Sirius ® inForm based on in situ UV–vis spectroscopy. %PDF-1.5 Here drog is found to be least solublein the distilled water whichmight be due to unionization of drug. ?~��������9yr4�4i1�&6Һ0���`�����Oǿn�`�������V N?��4�-�;���d�7�/�;9��=>E���Ne���~_0}�y�\�����;� z��'��qP�0�/�^ɰ�?�������"l��l�ۭ���t��J3�&�~����&�)��ݩA����]KX\�ٯ� ͆С� 9ݚq�KRٸths�_G_���HJi6֎�`��^7W�G��C�u�u�g7������ˌ�����f'�0�B�Pp����Fz����U���2p�r�ނ���q~�)R�$`�A덳c���4[��۴7��"��Mk�N`4N�����lء � %���� <> Saturation solubility studies Saturation solubility is a compound specific constant, only depending on the temperature and the properties of dissolution medium. 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